DNA test TNSTrapped neutrophil syndrome

Details about the disease

The bone marrow produces neutrophils (type of white blood cell) but is unable to effectively release them into the bloodstream. Affected puppies have an impaired immune system and will eventually die from infections they cannot fight. Once thought to be rare, it is now believed that the disease goes undiagnosed for several reasons.

Clinical signs

Because it is an autoimmune-deficiency disease, young puppies present a variety of clinical signs depending upon what infections they fall prone to. Thus many cases are not properly diagnosed and have just been thought to be "fading puppies". The age of onset varies depending on which infection is involved at the time. Most puppies become ill before leaving the breeder but some do not have clinical signs until later. Most affected puppies die or are euthanised by about 4 months of age.

How it is inherited

The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link http://www.thekennelclub.org.uk/health/for-breeders/dna-testing-simple-inherited-disorders/worldwide-dna-tests/

More Information

More information can be found at http://www.thekennelclub.org.uk/item/313
The BVA website can be found at www.bva.co.uk

Other schemes & tests currently available:

BVA/KC Hip Dysplasia Scheme

BVA/KC/ISDS Eye Scheme

DNA test - CEA/CH

DNA test - CL

DNA test - TNS

BVA/KC/ISDS Gonioscopy

The list above is not necessarily comprehensive, other available health tests can be found <here>