DNA test CEA/CHCollie eye anomaly / Choroidal hypoplasia

Details about the disease

CEA/CH causes abnormal development of the choroid - an important layer of tissue under the retina of the eye. Since the choroid layer does not develop normally from the start, the primary abnormality can be diagnosed at a very young age.

Clinical signs

The clinical effects vary greatly among affected dogs within one breed, between parent and offspring and even within a litter. Most often the disease presents as a mild form in affected dogs and the presence of the disease can only be detected upon ophthalmologic examination; the dog retains normal vision throughout life. However, dogs with mild disease can produce severely affected offspring. The severe form of the disease presents with related problems with the health of the eye that can result in serious vision loss in some cases.

How it is inherited

The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link http://www.thekennelclub.org.uk/health/for-breeders/dna-testing-simple-inherited-disorders/worldwide-dna-tests/

More Information

More information can be found at http://www.thekennelclub.org.uk/item/313
The BVA website can be found at www.bva.co.uk

Other schemes & tests currently available:

BVA/KC Hip Dysplasia Scheme

BVA/KC/ISDS Eye Scheme

DNA test - CEA/CH

DNA test - CL

DNA test - TNS

BVA/KC/ISDS Gonioscopy

The list above is not necessarily comprehensive, other available health tests can be found <here>